Polyozellin Explained

Polyozellin is a chemical which occurs in the mushroom Polyozellus multiplex. It inhibits prolyl endopeptidase, an enzyme that has a role in processing proteins (specifically, amyloid precursor protein) in Alzheimer's disease. Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects.^[1] Structurally related dibenzofuranyl derivatives of polyozellin are known as kynapcins.^[2]

Notes and References

1. Hwang JS, Song KS, Kim WG, Lee TH, Koshino H, Yoo ID . Polyozellin, a new inhibitor of prolyl endopeptidase from Polyozellus multiplex . The Journal of Antibiotics . 50 . 9 . 773–77 . 1997 . 9360624 . 10.7164/antibiotics.50.773. free .
2. Kim SI, Park IH, Song KS . kynapcin-13 and -28, new benzofuran prolyl endopeptidase inhibitors from Polyozellus multiplex . The Journal of Antibiotics . 55 . 7 . 623–28 . 2002 . 12243451 . 10.7164/antibiotics.55.623. free .