Polydiethylstilbestrol phosphate explained

Polydiethylstilbestrol phosphate (PSP, PDSP) is an estrogen medication which has been used in scientific research and has been studied for use in veterinary medicine as a livestock growth promoter.^{[1] [2] [3] [4] [5] [6]} It is a phosphate ester of diethylstilbestrol (DES) in the form of a polymer and is a polymeric form of fosfestrol (diethylstilbestrol diphosphate); PDSP acts as a long-lasting prodrug of DES. It has similarities to polyestradiol phosphate and polyestriol phosphate.

See also

• List of estrogen esters § Diethylstilbestrol esters
• Polytestosterone phloretin phosphate

Notes and References

1. Diczfalusy E, Fernö H, Fex B, Högberg B, Kneip P . High Molecular Weight Enzyme Inhibitors. IV. Polymeric Phosphates of Synthetic Estrogens. . Acta Chem. Scand. . 13 . 5 . 1011–1018 . 1959 . 10.3891/acta.chem.scand.13-1011. free .
2. Bengtsson G, Ullberg S, Perklev T . Autoradiographic Distribution Studies after Administration of a Macromolecular Synthetic Oestrogen (14C-Polydiethylstilboestrol Phosphate) . Acta Endocrinol. . 43 . 4. 571–80 . August 1963 . 14059878 . 10.1530/acta.0.0430571 .
3. Perklev T . Distribution and Excretion of Radioactivity after Parenteral Administration of Radioactive Polydiethylstilbestrol Phosphate to Rats and a Cow . Proc. Soc. Exp. Biol. Med. . 117 . 2. 394–8 . November 1964 . 14233451 . 10.3181/00379727-117-29590 . 28242978 .
4. Perklev T, Gassner FX, Martin RP, Huseby RA, Shimoda W . Excretion of radioactivity by human subjects after ingestion of liver from cattle treated with labeled polydiethylstilbestrol phosphate . Proc. Soc. Exp. Biol. Med. . 119 . 4 . 996–8 . 1965 . 5891085 . 10.3181/00379727-119-30359 . 43341013 .
5. Perklev T, Gassner FX, Hopwood ML . Distribution and excretion of 14C-labeled polydiethylstilbestrol phosphate in a steer . J. Anim. Sci. . 26 . 5 . 1094–100 . September 1967 . 6077168 . 10.2527/jas1967.2651094x .
6. Loew FM . The veterinarian and intensive livestock production: humane considerations . Can. Vet. J. . 13 . 10 . 229–33 . October 1972 . 4562986 . 1695928 .