Plumbagin Explained

Plumbagin or 5-hydroxy-2-methyl-1,4-naphthoquinone is an organic compound with the chemical formula . It is regarded as a toxin and it is genotoxic^[1] and mutagenic.^[2]

Plumbagin is a yellow dye,^[3] formally derived from naphthoquinone.

It is named after the plant genus Plumbago, from which it was originally isolated.^[4] It is also commonly found in the carnivorous plant genera Drosera and Nepenthes.^{[5] [6]} It is also a component of the black walnut drupe.

See also

• Juglone

Notes and References

1. Toxicology in Vitro . 23 . 2 . 2009 . 266–271 . Genotoxicity of plumbagin and its effects on catechol and NQNO-induced DNA damage in mouse lymphoma cells . Jemal Demma . Karl Hallberg . Björn Hellman . 10.1016/j.tiv.2008.12.007. 19124069 .
2. J Bacteriol . 1985 . 164 . 3 . 1309–1316 . 219331 . Toxicity and mutagenicity of plumbagin and the induction of a possible new DNA repair pathway in Escherichia coli . S B Farr . D O Natvig . T Kogoma . 10.1128/JB.164.3.1309-1316.1985 . amp . 2933393.
3. https://www.drugs.com/npp/black-walnut.html Black Walnut
4. van der Vijver . L. M. . Distribution of Plumbagin in the Plumbaginaceae . Phytochemistry . 1972 . 11 . 11 . 3247–3248 . 10.1016/S0031-9422(00)86380-3 .
5. Wang, W. . Luo, X. . Li, H. . Terahertz and Infrared Spectra of Plumbagin, Juglone, and Menadione . . 2010 . 39 . 3 . 82–88 .
6. Rischer, H. . Hamm, A. . Bringmann, G. . Nepenthes insignis Uses a C₂-Portion of the Carbon Skeleton of L-Alanine Acquired via its Carnivorous Organs, to Build up the Allelochemical Plumbagin . Phytochemistry . 2002 . 59 . 6 . 603–609 . 10.1016/S0031-9422(02)00003-1 . 11867092 .