Plasmepsin II explained

Plasmepsin II
Ec Number:	3.4.23.39
Cas Number:	159447-18-4

Plasmepsin II (aspartic hemoglobinase II, PFAPD) is an enzyme.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves the small molecule substrates such as Ala-Leu-Glu-Arg-Thr-Phe-Phe(NO₂)-Ser-Phe-Pro-Thr

This enzyme is present in malaria organism, Plasmodium.

Notes and References

1. Dame JB, Reddy GR, Yowell CA, Dunn BM, Kay J, Berry C . Sequence, expression and modeled structure of an aspartic proteinase from the human malaria parasite Plasmodium falciparum . Molecular and Biochemical Parasitology . 64 . 2 . 177–90 . April 1994 . 7935597 . 10.1016/0166-6851(94)90024-8 .
2. Gluzman IY, Francis SE, Oksman A, Smith CE, Duffin KL, Goldberg DE . Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway . The Journal of Clinical Investigation . 93 . 4 . 1602–8 . April 1994 . 8163662 . 294190 . 10.1172/JCI117140 .
3. Hill J, Tyas L, Phylip LH, Kay J, Dunn BM, Berry C . High level expression and characterisation of Plasmepsin II, an aspartic proteinase from Plasmodium falciparum . FEBS Letters . 352 . 2 . 155–8 . September 1994 . 7925966 . 10.1016/0014-5793(94)00940-6 . free .