Pivenfrine Explained

Pivenfrine, also known as pivalylphenylephrine or phenylephrine pivalate, is a sympathomimetic and mydriatic agent which was never marketed.[1] [2] [3] [4] It is the 3-pivalyl ester of phenylephrine. Pivenfrine has much greater lipophilicity than phenylephrine.[5] Higher lipophilicity is known to greatly improve corneal permeability, as in dipivefrine (epinephrine dipivalate).[6] Another related compound is etilefrine pivalate (ethylnorphenylephrine pivalate).

Notes and References

  1. Book: Elks, J. . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . Springer US . 2014 . 978-1-4757-2085-3 . 2024-09-01 . 61,1001.
  2. Book: Ganellin CR, Triggle DJ . Dictionary of Pharmacological Agents. 21 November 1996. CRC Press. 978-0-412-46630-4. 615–.
  3. Book: World Health Organization. International Nonproprietary Names (INN) for Pharmaceutical Substances. 2000. World Health Organization. 978-0-11-986227-0.
  4. Book: Korolkovas A . Essentials of medicinal chemistry. 1988. John Wiley & Sons, Incorporated. 978-0-471-88356-2.
  5. Web site: Pivenfrine . PubChem . 1 September 2024.
  6. Baranowski P, Karolewicz B, Gajda M, Pluta J . Ophthalmic drug dosage forms: characterisation and research methods . ScientificWorldJournal . 2014 . 861904 . 2014 . 24772038 . 3977496 . 10.1155/2014/861904 . free .

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