Pirlimycin Explained

Pirlimycin hydrochloride belongs to the lincosamide class of antimicrobials. Under the trade name Pirsue,^[1] it is used in the treatment of mastitis in cattle.^{[2] [3]} __TOC__

Activity

Pirlimycin is active against Gram-positive bacteria, specifically Staphylococcus aureus and coagulase negative species of Staphylococcus and Streptococcus. It has no activity against Gram-negative bacteria.^[4]

Mechanism of action

It is bacteriostatic and acts by inhibiting bacterial protein synthesis via binding with the 50S subunit of the ribosome.

Notes and References

1. http://www.pirsue.com/PAHimages/compliance_pdfs/US_EN_PS_compliance.pdf Pirsue Sterile Solution
2. Thornsberry C, Marler JK, Watts JL, Yancey RJ . Activity of pirlimycin against pathogens from cows with mastitis and recommendations for disk diffusion tests . Antimicrobial Agents and Chemotherapy . 37 . 5 . 1122–6 . May 1993 . 8517701 . 187914 . 10.1128/AAC.37.5.1122 .
3. Book: Hogeveen H . Mastitis in dairy production: current knowledge and future solutions . 2005 . Wageningen Academic Publishers . Wageningen . 978-90-76998-70-1 . 55 .
4. Web site: USP: Pirlimycin . 2009-06-28 . https://web.archive.org/web/20090509031543/http://www.usp.org/pdf/EN/veterinary/pirlimycin.pdf . 2009-05-09 . dead .