Piperocaine Explained

Piperocaine is a local anesthetic drug developed in the 1920s and used as its hydrochloride salt for infiltration and nerve blocks.

Synthesis

Alkylation between 3-chloropropyl benzoate [942-95-0] (1) and Pipicoline [109-05-7] (2) provides piperocaine (3).

See also

• Hexylcaine

Further reading

• Tiedt TN, Albuquerque EX, Bakry NM, Eldefrawi ME, Eldefrawi AT . Voltage- and time-dependent actions of piperocaine on the ion channel of the acetylcholine receptor . Molecular Pharmacology . 16 . 3 . 909–21 . November 1979 . 316855 . ^[1] </ref>

Notes and References

1. 1950-02-01. A Preliminary Study of the Efficiency of Piperocaine Hydrochloride as a Local Anesthetic in Dental Surgery. The Journal of the American Dental Association. en. 40. 2. 163–169. 10.14219/jada.archive.1950.0022. 0002-8177. Costich . Emmett R. . 15402120 .