Substituted piperazine explained

Substituted piperazines are a class of chemical compounds based on a piperazine core.[1] Some are used as recreational drugs and some are used in scientific research.[2]

List of substituted piperazines

Phenylpiperazines

See also: Phenylpiperazine.

ortho-Substituted

Enpiprazole is known to produce oCPP as a metabolite.

Enciprazine was initially anticipated to produce oMeOPP as a metabolite, but this turned out not to be the case.

meta-Substituted

Trazodone, nefazodone, mepiprazole, and others produce mCPP as a metabolite.

para-Substituted

Multiple substitutions

Others

Other arylpiperazines

Many azapirones such as buspirone, gepirone, and tandospirone produce 1-PP as a metabolite.

See also

Notes and References

  1. Laras . Y. . Garino . C. . Dessolin . J. . Weck . C. . Moret . V. . Rolland . A. . Kraus . J.-L. . 2009-02-01 . New N4-substituted piperazine naphthamide derivatives as BACE-1 inhibitors . Journal of Enzyme Inhibition and Medicinal Chemistry . 24 . 1 . 181–187 . 10.1080/14756360802048939 . 1475-6366 . 18770069. 85385527 .
  2. Alghamdi . Saad . Alshehri . Mohammed M. . Asif . Mohammad . The Neuropharmacological Potential of Piperazine Derivatives: A Mini- Review . Mini-Reviews in Organic Chemistry . 2022 . en . 19 . 7 . 798–810 . 10.2174/1570193x19666220119120211.