Substituted piperazine explained
Substituted piperazines are a class of chemical compounds based on a piperazine core.[1] Some are used as recreational drugs and some are used in scientific research.[2]
List of substituted piperazines
Phenylpiperazines
See also: Phenylpiperazine.
ortho-Substituted
Enpiprazole is known to produce oCPP as a metabolite.
Enciprazine was initially anticipated to produce oMeOPP as a metabolite, but this turned out not to be the case.
meta-Substituted
Trazodone, nefazodone, mepiprazole, and others produce mCPP as a metabolite.
para-Substituted
Multiple substitutions
- 2,3-Methylphenylpiperazine (DMPP)
- 3-Trifluoromethyl-4-chlorophenylpiperazine (TFMCPP)
Others
Other arylpiperazines
Many azapirones such as buspirone, gepirone, and tandospirone produce 1-PP as a metabolite.
See also
Notes and References
- Laras . Y. . Garino . C. . Dessolin . J. . Weck . C. . Moret . V. . Rolland . A. . Kraus . J.-L. . 2009-02-01 . New N4-substituted piperazine naphthamide derivatives as BACE-1 inhibitors . Journal of Enzyme Inhibition and Medicinal Chemistry . 24 . 1 . 181–187 . 10.1080/14756360802048939 . 1475-6366 . 18770069. 85385527 .
- Alghamdi . Saad . Alshehri . Mohammed M. . Asif . Mohammad . The Neuropharmacological Potential of Piperazine Derivatives: A Mini- Review . Mini-Reviews in Organic Chemistry . 2022 . en . 19 . 7 . 798–810 . 10.2174/1570193x19666220119120211.