Phytoene desaturase (neurosporene-forming) explained

Phytoene desaturase (neurosporene-forming)
Ec Number:	1.3.99.28

Phytoene desaturase (neurosporene-forming) (3-step phytoene desaturase, three-step phytoene desaturase, phytoene desaturase (ambiguous), CrtI (ambiguous)) is an enzyme with systematic name 15-cis-phytoene:acceptor oxidoreductase (neurosporene-forming).^{[1] [2]} This enzyme catalyses the following chemical reaction

15-cis-phytoene + 3 acceptor

\rightleftharpoons all-trans-neurosporene + 3 reduced acceptor (overall reaction)

(1a) 15-cis-phytoene + acceptor

\rightleftharpoons all-trans-phytofluene + reduced acceptor

(1b) all-trans-phytofluene + acceptor

\rightleftharpoons all-trans-zeta-carotene + reduced acceptor

(1c) all-trans-zeta-carotene + acceptor

\rightleftharpoons all-trans-neurosporene + reduced acceptor

This enzyme is involved in carotenoid biosynthesis.

See also

• Phytoene desaturase (lycopene-forming)
• 15-Cis-phytoene desaturase
• Phytoene desaturase (zeta-carotene-forming)
• Phytoene desaturase (3,4-didehydrolycopene-forming)

Notes and References

1. Raisig A, Bartley G, Scolnik P, Sandmann G . Purification in an active state and properties of the 3-step phytoene desaturase from Rhodobacter capsulatus overexpressed in Escherichia coli . Journal of Biochemistry . 119 . 3 . 559–64 . March 1996 . 8830054 . 10.1093/oxfordjournals.jbchem.a021278 .
2. Wang CW, Liao JC . Alteration of product specificity of Rhodobacter sphaeroides phytoene desaturase by directed evolution . The Journal of Biological Chemistry . 276 . 44 . 41161–4 . November 2001 . 11526111 . 10.1074/jbc.M105786200 . free .