| phosphoribosyl-AMP cyclohydrolase | |
| Ec Number: | 3.5.4.19 |
| Cas Number: | 37289-22-8 |
| Go Code: | 0004635 |
| Width: | 270 |
In enzymology, a phosphoribosyl-AMP cyclohydrolase is an enzyme that catalyzes the chemical reaction
1-(5-phosphoribosyl)-AMP + H2O
\rightleftharpoons
Thus, the two substrates of this enzyme are 1-(5-phosphoribosyl)-AMP and H2O, whereas its two products are 1-(5-phosphoribosyl)-5-[(5-] and phosphoribosylamino)methylideneaminoimidazole-4-carboxamide]].
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase. Other names in common use include PRAMP-cyclohydrolase, and phosphoribosyladenosine monophosphate cyclohydrolase. This enzyme participates in histidine metabolism.
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .