Phosphonopyruvate decarboxylase explained

Phosphonopyruvate decarboxylase
Ec Number:	4.1.1.82

The enzyme phosphonopyruvate decarboxylase catalyzes the chemical reaction

3-phosphonopyruvate

\rightleftharpoons 2-phosphonoacetaldehyde + CO₂

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-phosphonopyruvate carboxy-lyase (2-phosphonoacetaldehyde-forming). This enzyme is also called 3-phosphonopyruvate carboxy-lyase. This enzyme participates in aminophosphonate metabolism.

References

• Zhang G, Dai J, Lu Z, Dunaway-Mariano D . 2003 . The phosphonopyruvate decarboxylase from Bacteroides fragilis . J. Biol. Chem. . 278 . 41302 - 8 . 12904299 . 10.1074/jbc.M305976200 . 42 . free .
• Seidel HM, Knowles JR . 1994 . Interaction of inhibitors with phosphoenolpyruvate mutase: implications for the reaction mechanism and the nature of the active site . Biochemistry . 33 . 5641 - 6 . 8180189 . 10.1021/bi00184a037 . 18 .
• Nakashita H, Watanabe K, Hara O, Hidaka T, Seto H . Tokyo . Studies on the biosynthesis of bialaphos. Biochemical mechanism of C-P bond formation: discovery of phosphonopyruvate decarboxylase which catalyzes the formation of phosphonoacetaldehyde from phosphonopyruvate . J. Antibiot. . 212 - 9 . 9127192 . 3 . 50 . March 1997 . 10.7164/antibiotics.50.212. free .