Phosphonoacetaldehyde reductase (NADH) explained

Phosphonoacetaldehyde reductase (NADH)
Ec Number:	1.1.1.309

Phosphonoacetaldehyde reductase (NADH) (PhpC) is an enzyme with systematic name 2-hydroxyethylphosphonate:NAD⁺ oxidoreductase.^[1] This enzyme catalyses the following chemical reaction

2-hydroxyethylphosphonate + NAD⁺

\rightleftharpoons phosphonoacetaldehyde + NADH + H⁺

The enzyme from Streptomyces viridochromogenes catalyses a step in the biosynthesis of phosphinothricin tripeptide, the reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonate.

Notes and References

1. Blodgett JA, Thomas PM, Li G, Velasquez JE, van der Donk WA, Kelleher NL, Metcalf WW . Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide . Nature Chemical Biology . 3 . 8 . 480–5 . August 2007 . 17632514 . 4313788 . 10.1038/nchembio.2007.9 .