Phosphonate dehydrogenase explained

phosphonate dehydrogenase
Ec Number:	1.20.1.1
Go Code:	0050609

In enzymology, a phosphonate dehydrogenase is an enzyme that catalyzes the chemical reaction

phosphonate + NAD⁺ + H₂O

\rightleftharpoons phosphate + NADH + H⁺

The 3 substrates of this enzyme are phosphonate, NAD⁺, and H₂O, whereas its 3 products are phosphate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on phosphorus or arsenic in donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is phosphonate:NAD+ oxidoreductase. Other names in common use include NAD:phosphite oxidoreductase, and phosphite dehydrogenase.

References

• Costas AM, White AK, Metcalf WW . 2001 . Purification and characterization of a novel phosphorus-oxidizing enzyme from Pseudomonas stutzeri WM88 . J. Biol. Chem. . 276 . 17429 - 36 . 11278981 . 10.1074/jbc.M011764200 . 20 . free .
• Vrtis JM, White AK, Metcalf WW, van der Donk WA . 2001 . Phosphite dehydrogenase: an unusual phosphoryl transfer reaction . J. Am. Chem. Soc. . 123 . 2672 - 3 . 11456941 . 10.1021/ja004301k . 11 .