Phosphinothricin acetyltransferase explained

Phosphinothricin acetyltransferase
Ec Number:	2.3.1.183

Phosphinothricin acetyltransferase (PAT, PPT acetyltransferase, Pt-N-acetyltransferase, ac-Pt) is an enzyme with systematic name acetyl-CoA:phosphinothricin N-acetyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

\rightleftharpoons CoA + N-acetylphosphinothricin

The substrate phosphinothricin is used as a nonselective herbicide and is a potent inhibitor of EC 6.3.1.2.

Notes and References

1. Botterman J, Gosselé V, Thoen C, Lauwereys M . Characterization of phosphinothricin acetyltransferase and C-terminal enzymatically active fusion proteins . Gene . 102 . 1 . 33–7 . June 1991 . 1864506 . 10.1016/0378-1119(91)90534-i .
2. Droge-Laser W, Siemeling U, Puhler A, Broer I . The Metabolites of the Herbicide L-Phosphinothricin (Glufosinate) (Identification, Stability, and Mobility in Transgenic, Herbicide-Resistant, and Untransformed Plants) . Plant Physiology . 105 . 1 . 159–166 . May 1994 . 12232195 . 159341 . 10.1104/pp.105.1.159 .