Phosphatidylinositol diacylglycerol-lyase explained
| phosphatidylinositol diacylglycerol-lyase |
| Ec Number: | 4.6.1.13 |
| Cas Number: | 37288-19-0 |
| Go Code: | 0004436 |
The enzyme phosphatidylinositol diacylglycerol-lyase (EC 4.6.1.13) catalyzes the following reaction:
1-phosphatidyl-1D-myo-inositol = 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is 1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming). Other names in common use include monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, 1-phosphatidylinositol phosphodiesterase, 1-phosphatidyl-D-myo-inositol inositolphosphohydrolase, (cyclic-phosphate-forming), 1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase, and (1,2-cyclic-phosphate-forming). It participates in inositol phosphate metabolism.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .
References
- Allan D, Michell RH . 1974 . Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes. Activity at pH5.5 and pH7.0 . Biochem. J. . 142 . 591 - 7 . 4377210 . 3 . 10.1042/bj1420591 . 1168323 .
- Friedel RO, Brown JD, Durell . 1967 . Monophosphatidyl inositol inositolphosphohydrolase in guinea-pig brain . Biochim. Biophys. Acta . 144 . 684 - 6 . 4294905 . 3 . 10.1016/0005-2760(67)90059-8.
- Irvine RF . 1982 . The enzymology of stimulated inositol lipid turnover . Cell Calcium . 3 . 295 - 309 . 6297738 . 10.1016/0143-4160(82)90018-5 . 4–5 .
- Michell RH, Allan D . 1975 . Inositol cyclis phosphate as a product of phosphatidylinositol breakdown by phospholipase C (Bacillus cereus) . FEBS Lett. . 53 . 302 - 4 . 236918 . 10.1016/0014-5793(75)80041-X . 3 . 5813981 . free .
- Low MG, Finean JB . 1977 . Release of alkaline phosphatase from membranes by a phosphatidylinositol-specific phospholipase C . Biochem. J. . 167 . 281 - 4 . 588258 . 1 . 10.1042/bj1670281 . 1183647 .
- Henner DJ, Yang M, Chen E, Hellmiss R, Rodriguez H, Low MG . 1988 . Sequence of the Bacillus thuringiensis phosphatidylinositol specific phospholipase C . Nucleic Acids Res. . 16 . 10383 . 3194218 . 10.1093/nar/16.21.10383 . 21 . 338883 .
