Phosphatidylinositol deacylase explained

phosphatidylinositol deacylase
Ec Number:	3.1.1.52
Cas Number:	81604-94-6
Go Code:	0050185

The enzyme phosphatidylinositol deacylase (EC 3.1.1.52) catalyzes the reaction

1-phosphatidyl-D-myo-inositol + H₂O

\rightleftharpoons 1-acylglycerophosphoinositol + a carboxylate

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is 1-phosphatidyl-D-myo-inositol 2-acylhydrolase. Other names in common use include phosphatidylinositol phospholipase A₂, and phospholipase A₂.

References

• Gray NC, Strickland KP . 1982 . The purification and characterization of a phospholipase A₂ activity from the 106,000 X g pellet (microsomal fraction) of bovine brain acting on phosphatidylinositol . Can. J. Biochem. . 60 . 108 - 17 . 7083039 . 2 . 10.1139/o82-015.
• Gray NC, Strickland KP . 1982 . On the specificity of a phospholipase A₂ purified from the 106,000 X g pellet of bovine brain . Lipids . 17 . 91 - 6 . 7087686 . 10.1007/BF02535181 . 2 .