Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase explained

Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
Ec Number:3.1.3.86

Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase (EC 3.1.3.86, SHIP, p150Ship) is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase,[1] [2] [3] [4] [5] that has two isoforms: SHIP1 (produced by the gene INPP5D) and SHIP2 (INPPL1).

This enzyme catalyses the following chemical reaction

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O

\rightleftharpoons


1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate

This enzyme hydrolyses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2.

Notes and References

  1. Lioubin MN, Algate PA, Tsai S, Carlberg K, Aebersold A, Rohrschneider LR . p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity . Genes & Development . 10 . 9 . 1084–95 . May 1996 . 8654924 . 10.1101/gad.10.9.1084 . free .
  2. Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G . The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase . Proceedings of the National Academy of Sciences of the United States of America . 93 . 4 . 1689–93 . February 1996 . 8643691 . 40003 . 10.1073/pnas.93.4.1689 . free .
  3. Giuriato S, Payrastre B, Drayer AL, Plantavid M, Woscholski R, Parker P, Erneux C, Chap H . Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets . The Journal of Biological Chemistry . 272 . 43 . 26857–63 . October 1997 . 9341117 . 10.1074/jbc.272.43.26857 . free .
  4. Drayer AL, Pesesse X, De Smedt F, Woscholski R, Parker P, Erneux C . Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase . Biochemical and Biophysical Research Communications . 225 . 1 . 243–9 . August 1996 . 8769125 . 10.1006/bbrc.1996.1161 .
  5. Pesesse X, Moreau C, Drayer AL, Woscholski R, Parker P, Erneux C . The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity . FEBS Letters . 437 . 3 . 301–3 . October 1998 . 9824312 . 10.1016/S0014-5793(98)01255-1 . free .

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