Phosphatidylcholine desaturase explained
| phosphatidylcholine desaturase |
| Ec Number: | 1.14.19.22 |
| Cas Number: | 59929-36-1 |
| Go Code: | 0050184 |
In enzymology, a phosphatidylcholine desaturase (previously EC 1.3.1.35) is an enzyme that catalyzes the chemical reaction
1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NAD+
1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + NADH + H
+Thus, the two substrates of this enzyme are 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine and NAD+, whereas its 3 products are 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine:NAD+ Delta12-oxidoreductase. Other names in common use include oleate desaturase, linoleate synthase, oleoyl-CoA desaturase, and oleoylphosphatidylcholine desaturase.
References
- Pugh EL, Kates M . Characterization of a membrane-bound phospholipid desaturase system of candida lipolytica . Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism . 380 . 3 . 442–53 . March 1975 . 166662 . 10.1016/0005-2760(75)90112-5 .
- Slack CR, Roughan PG, Browse J . Evidence for an oleoyl phosphatidylcholine desaturase in microsomal preparations from cotyledons of safflower (Carthamus tinctorius) seed . The Biochemical Journal . 179 . 3 . 649–56 . June 1979 . 475773 . 1186674 . 10.1042/bj1790649 .
- Stymne S, Appelqvist LA . The biosynthesis of linoleate from oleoyl-CoA via oleoyl-phosphatidylcholine in microsomes of developing safflower seeds . European Journal of Biochemistry . 90 . 2 . 223–9 . October 1978 . 710426 . 10.1111/j.1432-1033.1978.tb12594.x . free .
