Phosalacine Explained

Phosalacine is a natural antimicrobial and herbicidal compound that has been isolated from the Actinobacteria Kitasatosporia phosalacinea.[1]

It is a tripeptide consisting of the amino acids glufosinate (phosphinothricin), alanine, and leucine.[2] It is similar in structure to bialaphos, differing by replacement of the terminal alanine with leucine.

Phosalacine has antimicrobial activity against Gram-positive and Gram-negative bacteria and some fungi.[1] It also shows herbicidal activity against alfalfa.[1] It is believed that the herbicidal activity is due to the slow release of glufosinate,[3] which is a commercially-used broad spectrum herbicide.

Notes and References

  1. 10.7164/antibiotics.37.829 . Phosalacine, a new herbicidal antibiotic containing phosphinothricin. Fermentation, isolation, biological activity and mechanism of action . 1984 . Omura . Satoshi . Murata . Masatsune . Hanaki . Hideaki . Hinotozawa . Kiyoizumi . Oiwa . Ruiko . Tanaka . Haruo . The Journal of Antibiotics . 37 . 8 . 829–835 . 6480502 . free .
  2. 10.7164/antibiotics.37.939 . The structure of phosalacine, a new herbicidal antibiotic containing phosphinothricin . 1984 . Omura . Satoshi . Hinotozawa . Kiyoizumi . Imamura . Nobutaka . Murata . Masatsune . The Journal of Antibiotics . 37 . 8 . 939–940 . 6480509 . 9186238 . free .
  3. Book: 10.1021/bk-1988-0380.ch013 . Naturally Occurring Carbon—Phosphorus Compounds as Herbicides . Biologically Active Natural Products . ACS Symposium Series . 1988 . Hoagland . Robert E. . 380 . 182–210 . 9780841215566 .

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