Phorbol 12,13-dibutyrate explained

Phorbol 12,13-dibutyrate (PDBu) is a phorbol ester which is one of the constituents of croton oil. As an activator of protein kinase C, it is a weak tumor promoter compared to 12-O-tetradecanoylphorbol-13-acetate.^[1]

PDBu is widely used as a chemical reagent because of its solubility in water and other organic solvents.

Notes and References

1. 10.1111/j.1749-6632.1983.tb47836.x. Blumberg PM, Delclos KB, Dunn JA, Jaken S, Leach KL, Yeh E . 1983 . Phorbol ester receptors and the in vitro effects of tumor promoters . Annals of the New York Academy of Sciences . 407 . 1 . 303–315. 6309054. 1983NYASA.407..303B . 20089027 .