Phloroisovalerophenone synthase explained

phloroisovalerophenone synthase
Ec Number:	2.3.1.156
Go Code:	0050634

In enzymology, a phloroisovalerophenone synthase is an enzyme that catalyzes the chemical reaction

isovaleryl-CoA + 3 malonyl-CoA

\rightleftharpoons 4 CoASH + 3 CO₂ + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one

Thus, the two substrates of this enzyme are isovaleryl-CoA and malonyl-CoA, whereas its 3 products are CoASH, CO₂, and 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is isovaleryl-CoA:malonyl-CoA acyltransferase. Other names in common use include valerophenone synthase, and 3-methyl-1-(trihydroxyphenyl)butan-1-one synthase.

References

• Verpoorte R . 1997 . Enzymes from the biosynthesis of hop alpha and beta acids . Proc. 26th Congr. Eur. Brew. . Conv. . 215 - 221 .
• Zuurbier KW, Leser J, Berger T, Hofte AJ, Schröder G, Verpoorte R, Schröder J . 4-Hydroxy-2-pyrone formation by chalcone and stilbene synthase with nonphysiological substrates . Phytochemistry . 49 . 7 . 1945–51 . December 1998 . 9883590 . 10.1016/S0031-9422(98)00346-X .