Phenylpyruvate tautomerase explained

phenylpyruvate tautomerase
Ec Number:5.3.2.1
Cas Number:9023-54-5
Go Code:0050178

In enzymology, phenylpyruvate tautomerase or Macrophage migration inhibitory factor is an enzyme that catalyzes the chemical reaction

\rightleftharpoons

enol-phenylpyruvate

Phenylpyruvate tautomerase has also been found to exhibit the same keto-enol tautomerism for 4-Hydroxyphenylpyruvic acid, which is structurally similar to phenylpyruvate but contains an additional hydroxyl moiety in the para position of the aromatic ring.[1]

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting keto- and enol-groups. The systematic name of this enzyme class is phenylpyruvate keto---enol-isomerase. This enzyme is also called phenylpyruvic keto-enol isomerase. This enzyme participates in tyrosine metabolism and phenylalanine metabolism.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes,,,,,, and .

References

Notes and References

  1. 9395080 . 417 . The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase . FEBS Lett . 85–8 . Rosengren E, Aman P, Thelin S, Hansson C, Ahlfors S, Björk P, Jacobsson L, Rorsman H . 1997 . 1 . 10.1016/s0014-5793(97)01261-1 . 27800700 . 1997FEBSL.417...85R .