Phenylethylmalonamide Explained

Phenylethylmalonamide (PEMA) is an active metabolite of the anticonvulsant drug primidone, although it is produced in a much lower concentration than phenobarbital, the other active metabolite.[1]

Notes and References

  1. El-Masri HA, Portier CJ . Physiologically based pharmacokinetics model of primidone and its metabolites phenobarbital and phenylethylmalonamide in humans, rats, and mice . Drug Metab. Dispos. . 26 . 6 . 585–94 . June 1998 . 9616196 .

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