Phenylalanine 2-monooxygenase explained

phenylalanine 2-monooxygenase
Ec Number:	1.13.12.9
Cas Number:	84012-76-0
Go Code:	0050172

In enzymology, a phenylalanine 2-monooxygenase is an enzyme that catalyzes the chemical reaction

L-phenylalanine + O₂

\rightleftharpoons 2-phenylacetamide + CO₂ + H₂O

Thus, the two substrates of this enzyme are L-phenylalanine and O₂, whereas its 3 products are 2-phenylacetamide, CO₂, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O with incorporation of one atom of oxygen (internal monooxygenases o internal mixed-function oxidases). The systematic name of this enzyme class is L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating). Other names in common use include L-phenylalanine oxidase (deaminating and decarboxylating), and phenylalanine (deaminating, decarboxylating)oxidase. This enzyme participates in phenylalanine metabolism.

References

• Koyama H . Tokyo . Purification and characterization of a novel L-phenylalanine oxidase (Deaminating and decarboxylating) from Pseudomonas sp. P-501 . J. Biochem. . 92. 1235 - 40 . 7174643 . 4 . October 1982.
• Koyama H . Tokyo . Oxidation and oxygenation of L-amino acids catalyzed by a L-phenylalanine oxidase (deaminating and decarboxylating) from Pseudomonas sp. P-501 . J. Biochem. . 96. 421 - 7 . 6501250 . 2 . August 1984.
• Koyama H . 1984 . A simple and rapid enzymatic determination of L-phenylalanine with a novel L-phenylalanine oxidase (deaminating and decarboxylating) from Pseudomonas sp. P-501 . Clin. Chim. Acta . 136 . 131 - 6 . 6692570 . 10.1016/0009-8981(84)90284-5 . 2–3 .
• Koyama H, Suzuki H . Tokyo . Spectral and kinetic studies on Pseudomonas L-phenylalanine oxidase (deaminating and decarboxylating) . J. Biochem. . 100. 859 - 66 . 3818566 . 4 . October 1986.