Phenylacetyl-CoA dehydrogenase explained

Phenylacetyl-CoA dehydrogenase
Ec Number:	1.17.5.1

In enzymology, a phenylacetyl-CoA dehydrogenase is an enzyme that catalyzes the chemical reaction

phenylacetyl-CoA + H₂O + 2 quinone

\rightleftharpoons phenylglyoxylyl-CoA + 2 quinol

The 3 substrates of this enzyme are phenylacetyl-CoA, H₂O, and quinone, whereas its two products are phenylglyoxylyl-CoA and quinol.

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH₂ groups with a quinone or similar compound as acceptor. The systematic name of this enzyme class is phenylacetyl-CoA:quinone oxidoreductase. This enzyme is also called phenylacetyl-CoA:acceptor oxidoreductase.

References

• Rhee SK, Fuchs G . 1999 . Phenylacetyl-CoA:acceptor oxidoreductase, a membrane-bound molybdenum–iron–sulfur enzyme involved in anaerobic metabolism of phenylalanine in the denitrifying bacterium Thauera aromatica . Eur. J. Biochem. . 262 . 507 - 15 . 10336636 . 10.1046/j.1432-1327.1999.00399.x . 2 .
• Schneider S, Fuchs G . 1998 . Phenylacetyl-CoA:acceptor oxidoreductase, a new α-oxidizing enzyme that produces phenylglyoxylate. Assay, membrane localization, and differential production in Thauera aromatica . Arch. Microbiol. . 169 . 509 - 16 . 9575237 . 10.1007/s002030050604 . 6 .