Phenylacetyl-CoA 1,2-epoxidase explained

Phenylacetyl-CoA 1,2-epoxidase
Ec Number:	1.14.13.149

Phenylacetyl-CoA 1,2-epoxidase (ring 1,2-phenylacetyl-CoA epoxidase, phenylacetyl-CoA monooxygenase, PaaAC, PaaABC(D)E) is an enzyme with systematic name phenylacetyl-CoA:oxygen oxidoreductase (1,2-epoxidizing).^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

phenylacetyl-CoA + NADPH + H⁺ + O₂

\rightleftharpoons 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + NADP⁺ + H₂O

Phenylacetyl-CoA 1,2-epoxidase participates in catabolism of phenylacetate in Escherichia coli and Pseudomonas putida.

Notes and References

1. Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G . Bacterial phenylalanine and phenylacetate catabolic pathway revealed . Proceedings of the National Academy of Sciences of the United States of America . 107 . 32 . 14390–5 . August 2010 . 20660314 . 2922514 . 10.1073/pnas.1005399107 . free .
2. Grishin AM, Ajamian E, Zhang L, Cygler M . Crystallization and preliminary X-ray analysis of PaaAC, the main component of the hydroxylase of the Escherichia coli phenylacetyl-coenzyme A oxygenase complex . Acta Crystallographica Section F . 66 . Pt 9 . 1045–9 . September 2010 . 20823522 . 2935223 . 10.1107/S174430911002748X .
3. Grishin AM, Ajamian E, Tao L, Zhang L, Menard R, Cygler M . Structural and functional studies of the Escherichia coli phenylacetyl-CoA monooxygenase complex . The Journal of Biological Chemistry . 286 . 12 . 10735–43 . March 2011 . 21247899 . 3060524 . 10.1074/jbc.M110.194423 . free .