Phenyl phosphorodiamidate explained

Phenyl phosphorodiamidate is an organophosphorus compound with the formula C₆H₅OP(O)(NH₂)₂. A white solid, it is used as an inhibitor of urease,^[1] an enzyme that accelerates the hydrolysis of urea. In this way, phenyl phosphorodiamidate enhances the effectiveness of urea-based fertilizers. It is a component of the technology of controlled release fertilizers.^[2]

In terms of its molecular structure, phenyl phosphorodiamidate is a tetrahedral molecule structurally related to urea, hence its inhibitory function. It is a derivative of phosphoryl chloride.

See also

• N-(n-butyl)thiophosphoric triamide, a related urease inhibitor

Notes and References

1. 10.1016/j.bioorg.2019.01.064. Synthesis, Crystal Structure and Biological Evaluation of New Phosphoramide Derivatives as Urease Inhibitors Using Docking, QSAR and Kinetic Studies. 2019. Gholivand. Khodayar. Pooyan. Mahsa. Mohammadpanah. Fahimeh. Pirastefar. Foroogh. Junk. Peter C.. Wang. Jun. Ebrahimi Valmoozi. Ali Asghar. Mani-Varnosfaderani. Ahmad. Bioorganic Chemistry. 86. 482–493. 30772649. 73460771.
2. 10.1016/j.agee.2016.08.019. Ammonia Volatilization from Synthetic Fertilizers and its Mitigation Strategies: A Global Synthesis. 2016. Pan. Baobao. Lam. Shu Kee. Mosier. Arvin. Luo. Yiqi. Chen. Deli. Agriculture, Ecosystems & Environment. 232. 283–289. 2016AgEE..232..283P .