Pheneturide Explained

Pheneturide (INN, BAN) (brand names Benuride, Deturid, Pheneturid, Septotence, Trinuride),^[1] also known as phenylethylacetylurea (or ethylphenacemide), is an anticonvulsant of the ureide class.^{[2] [3]} Conceptually, it can be formed in the body as a metabolic degradation product from phenobarbital. It is considered to be obsolete^[4] and is now seldom used.^[5] It is marketed in Europe, including in Poland, Spain and the United Kingdom.^[6] Pheneturide has a similar profile of anticonvulsant activity and toxicity relative to phenacemide.^{[7] [8]} As such, it is only used in cases of severe epilepsy when other, less-toxic drugs have failed. Pheneturide inhibits the metabolism and thus increases the levels of other anticonvulsants, such as phenytoin.

See also

• Phenacemide

Notes and References

1. Book: Muller. European Drug Index: European Drug Registrations, Fourth Edition. 19 June 1998. CRC Press. 978-3-7692-2114-5. 998–.
2. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 959–.
3. Byrne B, Rothchild R . 1H NMR studies of drugs with achiral and chiral lanthanide shift reagents: applications to the anticonvulsant pheneturide . Chirality . 11 . 7 . 529–35 . 1999 . 10423278 . 10.1002/(SICI)1520-636X(1999)11:7<529::AID-CHIR3>3.0.CO;2-K .
4. Book: Levy RH . Antiepileptic Drugs. 2002. Lippincott Williams & Wilkins. 978-0-7817-2321-3. 210–.
5. Book: Denham MJ . The Treatment of Medical Problems in the Elderly. 6 December 2012. Springer Science & Business Media. 978-94-011-6223-4. 335–.
6. Book: Vida, Julius . vanc . Anticonvulsants. 19 July 2013. Elsevier. 978-0-323-14395-0. 4,42.
7. Book: deStevens G, Zingel V, Leschke C, Hoeprich PD, Schultz RM, Mehrotra PK, Batra S, Bhaduri AP, Saxena AK, Saxena M . Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques. 11 November 2013. Birkhäuser. Basel. 978-3-0348-7161-7. 217–. 3 September 2016.
8. Book: Lancaster, Richard . vanc . Pharmacology in Clinical Practice. 22 October 2013. Elsevier. 978-1-4831-9294-9. 222–.