Phenacemide Explained

Phenacemide (INN, BAN) (brand name Phenurone), also known as phenylacetylurea, is an anticonvulsant of the ureide (acetylurea) class.^[1] It is a congener and ring-opened analogue of phenytoin (a hydantoin),^{[2] [3]} and is structurally related to the barbiturates and to other hydantoins.^[4] Phenacemide was introduced in 1949 for the treatment of epilepsy, but was eventually withdrawn due to toxicity.

See also

• Pheneturide

Further reading

• Coker SB . The use of phenacemide for intractable partial complex epilepsy in children . Pediatric Neurology . 2 . 4 . 230–232 . 1986 . 3508693 . 10.1016/0887-8994(86)90053-6 .
• Coker SB, Holmes EW, Egel RT . Phenacemide therapy of complex partial epilepsy in children: determination of plasma drug concentrations . Neurology . 37 . 12 . 1861–1866 . December 1987 . 3683877 . 10.1212/wnl.37.12.1861 . 219205208 .

Notes and References

1. Book: Ganellin CR, Triggle DJ . Dictionary of Pharmacological Agents. 21 November 1996. CRC Press. 978-0-412-46630-4. 1578–.
2. Book: Prasad JP . Central Nervous System . Conceptual Pharmacology. https://books.google.com/books?id=s0e_FlM8LKYC&pg=PA236. 2010. Universities Press. 978-81-7371-679-9. 236–.
3. Book: Saxena AK, Saxena M . Developments in anticonvulsants . Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques . Progress in Drug Research. Fortschritte der Arzneimittelforschung. Progres des Recherches Pharmaceutiques . deStevens G, Zingel V, Leschke C, Hoeprich P, Schultz R, Mehrotra P, Batra S, Bhaduri A, Saxena A, Saxena M . 6 . 44 . 185–291 . 1995 . 7644666 . 10.1007/978-3-0348-7161-7_6 . Birkhäuser. Basel . 978-3-0348-7161-7 .
4. Book: Kadam SS, Mahadik KR, Bothara KG . Central Nervous System Depresants . Principles of Medicinal Chemistry . II . https://books.google.com/books?id=Z7Pb3lJuRksC&pg=PA147. 1 July 2007. Pragati Books Pvt. Ltd.. 978-81-85790-03-9. 147–.