Petasin Explained

Petasin is a natural chemical compound found in plants of the genus Petasites. Chemically, it is classified as a sesquiterpene and is the ester of petasol and angelic acid.

Petasin is believed to be responsible, at least in part, for the anti-inflammatory effects of common butterbur (Petasites hybridus) extracts.[1]

A 2021 study reported that petasin can inhibit tumor growth and metastasis in an animal model of cancer.[2]

Notes and References

  1. 10.1016/S0006-2952(01)00552-4 . Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus . 2001 . Thomet . O . . 61 . 8 . 1041–7 . 11286996 . Wiesmann . UN . Schapowal . A . Bizer . C . Simon . HU .
  2. 10.1172/JCI139933 . Petasin potently inhibits mitochondrial complex I–based metabolism that supports tumor growth and metastasis . 2021 . Heishima . Kazuki . . 131 . 17 . e139933 . Sugito . Nobuhiko . Soga . Tomoyoshi . Nishikawa . Masashi . Ito . Yuko . free . 8409585 .

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