Perimycin Explained

Perimycin, also known as aminomycin and fungimycin, is polyene antibiotic produced by Streptomyces coelicolor var. aminophilus.^{[1] [2] [3] [4]} The compound exhibits antifungal properties.__TOC__

Composition

Perimycin is produced naturally as a mixture of three types: A, B and C, with type A being the major component. All types consist of a polyketide core with a perosamine sugar moiety. The variations occur at the end of the core opposite the perosamine moiety. Perimycin A has an aromatic group in this position, whereas the identities of the analogous groups in the other perimycin types are currently undetermined.

Usage

Polyene antibiotics in general are often toxic to humans and have poor bioavailability. Thus, with the notable exception of amphotericin B, they are often not used clinically. Perimycin has been shown to be an effective antifungal compound, but is not widely used in clinical settings.^[5]

Notes and References

1. Hamilton-Miller JM . Chemistry and biology of the polyene macrolide antibiotics . Bacteriological Reviews . 37 . 2 . 166–96 . June 1973 . 10.1128/br.37.2.166-196.1973 . 4578757 . 413810.
2. Liu CM, McDaniel LE, Schaffner CP . Fungimycin, biogenesis of its aromatic moiety . The Journal of Antibiotics . 25 . 3 . 187–8 . March 1972 . 5034814 . 10.7164/antibiotics.25.187 . free .
3. Lee CH, Schaffner CP . Perimycin. The structure of some degradation products . Tetrahedron . 25 . 10 . 2229–32 . May 1969 . 5788396 . 10.1016/S0040-4020(01)82770-8.
4. Pawlak J, Sowiński P, Borowski E, Gariboldi P . Stereostructure of perimycin A . The Journal of Antibiotics . 48 . 9 . 1034–8 . September 1995 . 7592049 . 10.7164/antibiotics.48.1034 . free .
5. 10.1016/j.ajo.2009.01.020. 19327742. Elmer. Y. Tu . Charlotte E. Joslina . Lisa M. Nijmc . Robert S. Federd . Sandeep Jaina . Megan E. Shoffe. Polymicrobial Keratitis: Acanthamoeba and Infectious Crystalline Keratopathy. July 2009. American Journal of Ophthalmology. 148. 1. 13–19.e2. 2830559.