Perakine reductase explained

Perakine reductase
Ec Number:	1.1.1.317

Perakine reductase is an enzyme with systematic name raucaffrinoline:NADP⁺ oxidoreductase.^{[1] [2]} This enzyme catalyses the following chemical reaction

raucaffrinoline + NADP⁺

\rightleftharpoons perakine + NADPH + H⁺

The biosynthesis of raucaffrinoline from perakine is a side route of the ajmaline biosynthesis pathway.

Notes and References

1. Sun L, Ruppert M, Sheludko Y, Warzecha H, Zhao Y, Stöckigt J . Purification, cloning, functional expression and characterization of perakine reductase: the first example from the AKR enzyme family, extending the alkaloidal network of the plant Rauvolfia . Plant Molecular Biology . 67 . 5 . 455–67 . July 2008 . 18409028 . 10.1007/s11103-008-9331-7 .
2. Rosenthal C, Mueller U, Panjikar S, Sun L, Ruppert M, Zhao Y, Stöckigt J . Expression, purification, crystallization and preliminary X-ray analysis of perakine reductase, a new member of the aldo-keto reductase enzyme superfamily from higher plants . Acta Crystallographica Section F . 62 . Pt 12 . 1286–9 . December 2006 . 17142919 . 2225361 . 10.1107/S174430910605041X .