Peptidyl-glutaminase explained

peptidyl-glutaminase
Ec Number:	3.5.1.43
Cas Number:	37228-70-9
Go Code:	0050170

In enzymology, a peptidyl-glutaminase is an enzyme that catalyzes the chemical reaction

alpha-N-peptidyl-L-glutamine + H₂O

\rightleftharpoons alpha-N-peptidyl-L-glutamate + NH₃

Thus, the two substrates of this enzyme are alpha-N-peptidyl-L-glutamine and H₂O, whereas its two products are alpha-N-peptidyl-L-glutamate and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is peptidyl-L-glutamine amidohydrolase. Other names in common use include peptidoglutaminase I, peptideglutaminase, and peptidoglutaminase.

References

• Kikuchi M, Hayashida H, Nakano E, Sakaguchi K . 1971 . Peptidoglutaminase. Enzymes for selective deamidation of gamma-amide of peptide-bound glutamine . Biochemistry . 10 . 1222 - 9 . 4928623 . 10.1021/bi00783a019 . 7 .