Signaling peptide receptor explained

Signaling peptide receptor is a type of receptor which binds one or more signaling peptides or signaling proteins.

An example is the tropomyosin receptor kinase B (TrkB), which is bound and activated by the neurotrophic protein brain-derived neurotrophic factor (BDNF). Another example is the μ-opioid receptor (MOR), which is bound and activated by the opioid peptide hormone β-endorphin.

Adiponectin receptor

See main article: Adiponectin receptor.

AdipoR₁

See main article: Adiponectin receptor 1.

• Agonists
  • Peptide
    • Adiponectin
    • ADP-355
    • ADP-399
  • Non-peptide
    • AdipoRon
    • (–)-Arctigenin
    • Arctiin
    • Gramine
    • Matairesinol
• Antagonists
  • Peptide
    • ADP-400

AdipoR₂

See main article: Adiponectin receptor 2.

• Agonists
  • Peptide
    • Adiponectin
    • ADP-355
    • ADP-399
  • Non-peptide
    • AdipoRon
    • Deoxyschizandrin
    • Parthenolide
    • Syringing
    • Taxifoliol
• Antagonists
  • Peptide
    • ADP-400

Angiotensin receptor

See main article: Angiotensin receptor.

Bradykinin receptor

See main article: Bradykinin receptor.

• Agonists
  • Bradykinin
  • Kallidin
• Antagonists
  • FR-173657
  • Icatibant
  • LF22-0542

Calcitonin gene-related peptide receptor

See main article: Calcitonin gene-related peptide receptor.

• Agonists
  • Amylin
  • CGRP
  • Pramlintide
• Antagonists
  • Atogepant
  • BI 44370 TA
  • CGRP (8-37)
  • MK-3207
  • Olcegepant
  • Rimegepant
  • SB-268262
  • Telcagepant
  • Ubrogepant
• Antibodies
  • Eptinezumab
  • Erenumab
  • Fremanezumab
  • Galcanezumab

Cholecystokinin receptor

See main article: Cholecystokinin receptor.

CCK_A

See main article: Cholecystokinin A receptor.

• Agonists
  • Cholecystokinin
• Antagonists
  • Amiglumide
  • Asperlicin
  • Devazepide
  • Dexloxiglumide
  • Lintitript
  • Lorglumide
  • Loxiglumide
  • Pranazepide
  • Proglumide
  • Tarazepide
  • Tomoglumide

CCK_B

See main article: Cholecystokinin B receptor.

• Agonists
  • Cholecystokinin
  • CCK-4
  • Gastrin
  • Pentagastrin (CCK-5)
• Antagonists
  • Ceclazepide
  • CI-988 (PD-134308)
  • Itriglumide
  • L-365,360
  • Netazepide
  • Proglumide
  • Spiroglumide

Unsorted

• Antagonists
  • Nastorazepide

Corticotropin-releasing hormone receptor

See main article: Corticotropin-releasing hormone receptor.

CRF₁

See main article: Corticotropin-releasing hormone receptor 1.

• Agonists
  • Cortagine
  • Corticorelin
  • Corticotropin-releasing hormone
  • Sauvagine
  • Stressin I
  • Urocortin
• Antagonists
  • Antalarmin
  • Astressin-B
  • CP-154,526
  • Emicerfont
  • Hypericin
  • LWH-234
  • NBI-27914
  • NBI-74788
  • Pexacerfont
  • R-121919
  • TS-041
  • Verucerfont

CRF₂

See main article: Corticotropin-releasing hormone receptor 2.

• Agonists
  • Corticorelin
  • Corticotropin-releasing hormone
  • Sauvagine
  • Urocortin
• Antagonists
  • Astressin-B

Cytokine receptor

See main article: Cytokine receptor.

Endothelin receptor

See main article: Endothelin receptor.

• Agonists
  • Endothelin 1
  • Endothelin 2
  • Endothelin 3
  • IRL-1620
  • Sarafotoxin
• Antagonists
  • A-192621
  • Ambrisentan
  • Aprocitentan
  • Atrasentan
  • Avosentan
  • Bosentan
  • BQ-123
  • BQ-788
  • Clazosentan
  • Darusentan
  • Edonentan
  • Enrasentan
  • Fandosentan
  • Feloprentan
  • Macitentan
  • Nebentan
  • Sitaxentan
  • Sparsentan
  • Tezosentan
  • Zibotentan

Galanin receptor

See main article: Galanin receptor.

GAL₁

See main article: Galanin receptor 1.

• Agonists
  • Galanin
  • Galanin (1-15)
  • Galanin-like peptide
  • Galmic
  • Galnon
  • NAX 810-2
• Antagonists
  • C7
  • Dithiepine-1,1,4,4-tetroxide
  • Galantide (M15)
  • M32
  • M35
  • M40
  • SCH-202596

GAL₂

See main article: Galanin receptor 2.

• Agonists
  • Galanin
  • Galanin (1-15)
  • Galanin (2-11)
  • Galanin-like peptide
  • Galmic
  • Galnon
  • J18
  • NAX 810-2
• Antagonists
  • C7
  • Galantide (M15)
  • M32
  • M35
  • M40
  • M871

GAL₃

See main article: Galanin receptor 3.

• Agonists
  • Galanin
  • Galanin (1-15)
  • Galmic
  • Galnon
• Antagonists
  • C7
  • Galantide (M15)
  • GalR3ant
  • HT-2157
  • M32
  • M35
  • M40
  • SNAP-37889
  • SNAP-398299

Growth hormone secretagogue receptor

See main article: Growth hormone secretagogue receptor.

Growth hormone receptor

See main article: Growth hormone receptor.

Growth-hormone-releasing hormone receptor

See main article: Growth-hormone-releasing hormone receptor.

Glucagon-like peptide receptor

GLP-1

See main article: Glucagon-like peptide-1 receptor.

• Agonists
  • Albiglutide
  • Beinaglutide
  • Dulaglutide
  • Efpeglenatide
  • Exenatide
  • GLP-1
  • Langlenatide
  • Liraglutide
  • Lixisenatide
  • Oxyntomodulin
  • Pegapamodutide
  • Semaglutide
  • Taspoglutide

GLP-2

See main article: Glucagon-like peptide-2 receptor.

• Agonists
  • Apraglutide
  • Elsiglutide
  • Glepaglutide
  • GLP-2
  • Teduglutide

Others

• Propeptides
  • Preproglucagon
  • Proglucagon

Glucagon receptor

See main article: Glucagon receptor.

• Agonists
  • Dasiglucagon
  • Glucagon
  • Oxyntomodulin
• Antagonists
  • Adomeglivant
  • L-168,049
  • LGD-6972
• Propeptides
  • Preproglucagon
  • Proglucagon

Gonadotropin-releasing hormone receptor

See main article: Gonadotropin-releasing hormone receptor.

Gonadotropin receptor

See main article: Gonadotropin receptor.

Growth factor receptor

See main article: Growth factor receptor.

Insulin receptor

See main article: Insulin receptor.

• Agonists
  • Chaetochromin (4548-G05)
  • Insulin-like growth factor 1
  • Insulin-like growth factor 2
  • Insulin
  • Insulin aspart
  • Insulin degludec
  • Insulin detemir
  • Insulin glargine
  • Insulin glulisine
  • Insulin lispro
  • Mecasermin
  • Mecasermin rinfabate
• Antagonists
  • BMS-754807
  • S661
  • S961
• Kinase inhibitors
  • Linsitinib
• Antibodies
  • Xentuzumab (against IGF-1 and IGF-2)

KiSS1-derived peptide receptor

See main article: KiSS1-derived peptide receptor.

• Agonists
  • Kisspeptin (kisspeptin-54, metastin)
  • Kisspeptin-10
  • KISS1-305
  • MVT-602 (RVT-602, TAK-448)
  • TAK-683
• Antagonists
  • Kisspeptin-234

Leptin receptor

See main article: Leptin receptor.

• Agonists
  • Leptin
  • Metreleptin

Melanin-concentrating hormone receptor

See main article: Melanin-concentrating hormone receptor.

MCH₁

See main article: Melanin-concentrating hormone receptor 1.

• Agonists
  • Melanin-concentrating hormone
• Antagonists
  • ATC-0065
  • ATC-0175
  • GW-803430
  • NGD-4715
  • SNAP-7941
  • SNAP-94847

MCH₂

See main article: Melanin-concentrating hormone receptor 2.

• Agonists
  • Melanin-concentrating hormone

Melanocortin receptor

See main article: Melanocortin receptor.

Neuropeptide FF receptor

See main article: Neuropeptide FF receptor.

• Agonists
  • Neuropeptide AF
  • Neuropeptide FF
  • Neuropeptide SF (RFRP-1)
  • Neuropeptide VF (RFRP-3)
• Antagonists
  • BIBP-3226
  • RF9

Neuropeptide S receptor

See main article: Neuropeptide S receptor.

• Agonists
  • Neuropeptide S
• Antagonists
  • ML-154
  • SHA-68

Neuropeptide Y receptor

See main article: Neuropeptide Y receptor.

Y₁

See main article: Neuropeptide Y receptor Y1.

• Agonists
  • Neuropeptide Y
  • Peptide YY
• Antagonists
  • BIBO-3304
  • BIBP-3226
  • BVD-10
  • GR-231118
  • PD-160170

Y₂

See main article: Neuropeptide Y receptor Y2.

• Agonists
  • 2-Thiouridine 5'-triphosphate
  • Neuropeptide Y
  • Neuropeptide Y (13-36)
  • Peptide YY
  • Peptide YY (3-36)
• Antagonists
  • BIIE-0246
  • JNJ-5207787
  • SF-11

Y₄

• Agonists
  • GR-231118
  • Neuropeptide Y
  • Pancreatic polypeptide
  • Peptide YY
• Antagonists
  • UR-AK49

Y₅

See main article: Neuropeptide Y receptor Y5.

• Agonists
  • BWX-46
  • Neuropeptide Y
  • Peptide YY
• Antagonists
  • CGP-71683
  • FMS-586
  • L-152,804
  • Lu AA-33810
  • MK-0557
  • NTNCB
  • Velneperit (S-2367)

Neurotensin receptor

See main article: Neurotensin receptor.

NTS₁

See main article: Neurotensin receptor 1.

• Agonists
  • Neurotensin
  • Neuromedin N
• Antagonists
  • Meclinertant
  • SR-142948

NTS₂

See main article: Neurotensin receptor 2.

• Agonists
  • Neurotensin
• Antagonists
  • Levocabastine
    • SR-142948

Opioid receptor

See main article: Opioid receptor.

Orexin receptor

See main article: Orexin receptor.

Oxytocin receptor

See main article: Oxytocin receptor.

Prolactin receptor

See main article: Prolactin receptor.

Parathyroid hormone receptor

See main article: Parathyroid hormone receptor.

• Agonists
  • Abaloparatide
  • Parathyroid hormone
  • Parathyroid hormone-related protein (PTHrP)
  • Semparatide
  • Teriparatide

Relaxin receptor

See main article: Relaxin receptor.

• Agonists
  • Insulin-like factor 3
  • Relaxin (1, 2, 3)
  • Serelaxin

Somatostatin receptor

See main article: Somatostatin receptor.

Tachykinin receptor

See main article: Tachykinin receptor.

Thyrotropin-releasing hormone receptor

See main article: Thyrotropin-releasing hormone receptor.

• Agonists
  • Azetirelin
  • JTP-2942
  • Montirelin
  • Orotirelin
  • Posatirelin
  • Protirelin
  • Rovatirelin
  • RX-77368 (thymoliberin)
  • Taltirelin
  • TRH (TRF)

Thyrotropin receptor

See main article: Thyrotropin receptor.

• Agonists
  • Thyrotropin alfa
  • TSH (thyrotropin)

Vasopressin receptor

See main article: Vasopressin receptor.

Vasoactive intestinal peptide receptor and Pituitary adenylate cyclase-activating peptide

See main article: Vasopressin receptor.

VIPR₁

See main article: VIPR1.

• Agonists
  • Peptide
    • Bay 55-9837
    • LBT-3393
    • PACAP
    • VIP

VIPR₂

See main article: VIPR2.

• Agonists
  • Peptide
    • LBT-3627
    • PACAP
    • VIP

PAC₁

See main article: ADCYAP1R1.

• Agonists
  • PACAP
  • PACAP (1-27)
  • PACAP (1-38)
• Antagonists
  • PACAP (6-38)

Unsorted

• PHI
• PHM
• PHV

Others

• Endogenous
  • Adrenomedullin
  • Apelin
  • Asprosin
  • Bombesin
  • Calcitonin
  • Carnosine
  • CART
  • CLIP
  • DSIP
  • Enteroglucagon
  • Formyl peptide
  • GALP
  • GIP
  • GRP
  • Integrin ligands
    • collagens
    • fibrinogen
    • fibronectin
    • laminins
    • ICAM-1
    • ICAM-2
    • osteopontin
    • VCAM-1
    • vitronectin
  • Kininogens
  • Motilin
  • Natriuretic peptides
    • ANP
    • BNP
    • CNP
    • urodilatin
  • Nesfatin-1
  • Neuromedin B
  • Neuromedin N
  • Neuromedin S
  • Neuromedin U
  • Obestatin
  • Osteocalcin
  • Resistin
  • Secretin
  • Thymopoietin
  • Thymosins
  • Thymulin
  • Urotensin-II
  • VGF
• Exogenous
  • Lifitegrast (LFA-1 antagonist)

See also

• Neuropeptide receptor
• Neurotransmitter receptor