Peptide-methionine (R)-S-oxide reductase explained

Peptide-methionine (R)-S-oxide reductase
Ec Number:	1.8.4.12

In enzymology, a peptide-methionine (R)-S-oxide reductase is an enzyme that catalyzes the chemical reaction

peptide-L-methionine + thioredoxin disulfide + H₂O

\rightleftharpoons peptide-L-methionine (R)-S-oxide + thioredoxin

The 3 substrates of this enzyme are peptide-L-methionine, thioredoxin disulfide, and H₂O, whereas its two products are peptide-L-methionine (R)-S-oxide and thioredoxin.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with a disulfide as acceptor. The systematic name of this enzyme class is peptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming]. Other names in common use include MsrB, methionine sulfoxide reductase (ambiguous), pMSR, methionine S-oxide reductase (ambiguous), selenoprotein R, methionine S-oxide reductase (R-form oxidizing), methionine sulfoxide reductase B, SelR, SelX, PilB, and pRMsr.

References

• Moskovitz J . 2002 . Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity . Biochem. Biophys. Res. Commun. . 290 . 62 - 5 . 11779133 . 10.1006/bbrc.2001.6171 . Singh . VK . Requena . J . Wilkinson . BJ . Jayaswal . RK . Stadtman . ER . 1 .
• Taylor AB, Benglis DM, Dhandayuthapani S, Hart PJ . 2003 . Structure of Mycobacterium tuberculosis methionine sulfoxide reductase A in complex with protein-bound methionine . J. Bacteriol. . 185 . 4119 - 26 . 12837786 . 10.1128/JB.185.14.4119-4126.2003 . 14 . 164888 .
• Singh VK, Moskovitz J . 2003 . Multiple methionine sulfoxide reductase genes in Staphylococcus aureus: expression of activity and roles in tolerance of oxidative stress . Microbiology . 149 . 2739 - 47 . 14523107 . 10.1099/mic.0.26442-0 . Pt 10 . free .
• Boschi-Muller S, Olry A, Antoine M, Branlant G . 2005 . The enzymology and biochemistry of methionine sulfoxide reductases . Biochim. Biophys. Acta . 1703 . 231 - 8 . 15680231 . 2 . 10.1016/j.bbapap.2004.09.016 .
• Ezraty B, Aussel L, Barras F . 2005 . Methionine sulfoxide reductases in prokaryotes . Biochim. Biophys. Acta . 1703 . 221 - 9 . 15680230 . 2 . 10.1016/j.bbapap.2004.08.017 .
• Weissbach H, Resnick L, Brot N . 2005 . Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage . Biochim. Biophys. Acta . 1703 . 203 - 12 . 15680228 . 2 . 10.1016/j.bbapap.2004.10.004 .
• Kauffmann B, Aubry A, Favier F . 2005 . The three-dimensional structures of peptide methionine sulfoxide reductases: current knowledge and open questions . Biochim. Biophys. Acta . 1703 . 249 - 60 . 15680233 . 2 . 10.1016/j.bbapap.2004.09.008 .
• Vougier S, Mary J, Friguet B . 2003 . Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells . Biochem. J. . 373 . 531 - 7 . 12693988 . 10.1042/BJ20030443 . Pt 2 . 1223498 .
• Dorsselear A, Branlant G . 2002 . Characterization of the methionine sulfoxide reductase activities of PILB, a probable virulence factor from Neisseria meningitidis . J. Biol. Chem. . 277 . 12016 - 22 . 11812798 . 10.1074/jbc.M112350200 . 14 . free .
• Sagher D, Brunell D, Hejtmancik JF, Kantorow M, Brot N, Weissbach H . 2006 . Thionein can serve as a reducing agent for the methionine sulfoxide reductases . Proc. Natl. Acad. Sci. U.S.A. . 103 . 8656 - 61 . 16735467 . 10.1073/pnas.0602826103 . 23 . 1592241 . free .