Peptide-O-fucosyltransferase explained
| peptide-O-fucosyltransferase |
| Ec Number: | 2.4.1.221 |
| Cas Number: | 9033-08-3 |
| Go Code: | 0046922 |
In enzymology, a peptide-O-fucosyltransferase is an enzyme that catalyzes the chemical reaction in which an alpha-L-fucosylpyranoside residue is transferred from GDP-beta-L-fucose to the sidechain oxygen atom of a serine or threonine residue in a protein.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase. Other names in common use include GDP-L-fucose:polypeptide fucosyltransferase, GDP-fucose protein O-fucosyltransferase, and GDP-fucose:polypeptide fucosyltransferase.
References
- Wang Y, Spellman MW . 1998 . Purification and characterization of a GDP-fucose:polypeptide fucosyltransferase from Chinese hamster ovary cells . J. Biol. Chem. . 273 . 8112 - 8 . 9525914 . 10.1074/jbc.273.14.8112 . 14 . free .
- Haltiwanger RS . 2001 . Modification of epidermal growth factor-like repeats with O-fucose Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase . J. Biol. Chem. . 276 . 40338 - 45 . 11524432 . Shao . L . Shi . S . Harris . RJ . Spellman . MW . Stanley . P . Haltiwanger . RS . 43 . 10.1074/jbc.M107849200 . free .
- Wang Y, Lee GF, Kelley RF, Spellman MW . 1996 . Identification of a GDP-L-fucose:polypeptide fucosyltransferase and enzymatic addition of O-linked fucose to EGF domains . Glycobiology . 6 . 837 - 42 . 9023546 . 10.1093/glycob/6.8.837 . 8 . free .
- Peter-Katalinic J . 2001 . C-mannosylation and O-fucosylation of the thrombospondin type 1 module . J. Biol. Chem. . 276 . 6485 - 98 . 11067851 . 10.1074/jbc.M008073200 . Huwiler . KG . Macek . B . Hess . D . Lawler . J . Mosher . DF . Peter-Katalinic . J . 9 . free .
