Pentylone Explained

Pentylone is a stimulant developed in the 1960s.^[1] It is a substituted cathinone that has been identified in some samples of powders sold as "NRG-1", along with varying blends of other cathinone derivatives including flephedrone, MDPBP, MDPV, and 4-MePPP. It was also found in combination with 4-MePPP being sold as "NRG-3".^[2] Reports indicate side effects include paranoia, agitation, and insomnia, with effects lasting for several days at high doses.^[3]

Pharmacology

Pentylone acts as a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) and a serotonin releasing agent.^[4]

Legality

Pentylone is banned in Canada, Germany, Sweden, the United States, and the United Kingdom.^{[5] [6]}

See also

• α-PVP
• Dipentylone
• Methylenedioxypyrovalerone (MDPV)
• Methyl-K
• N-Ethylpentylone
• Pentedrone

Notes and References

1. Substituted phenyl-α-amino ketones. . GB . 1085135 . 1969 .
2. Brandt SD, Freeman S, Sumnall HR, Measham F, Cole J . Analysis of NRG 'legal highs' in the UK: identification and formation of novel cathinones . Drug Testing and Analysis . 3 . 9 . 569–575 . September 2011 . 21960541 . 10.1002/dta.204 .
3. Bish J . Watch Out for Pentylone, the Horrible New MDMA Additive . Vice . 4 August 2017 .
4. Simmler LD, Rickli A, Hoener MC, Liechti ME . Monoamine transporter and receptor interaction profiles of a new series of designer cathinones . Neuropharmacology . 79 . 152–160 . April 2014 . 24275046 . 10.1016/j.neuropharm.2013.11.008 . 25259854 .
5. Web site: Cannabinoider föreslås bli klassade som hälsofarlig vara . Cannabinoids are proposed to be classified as a health hazard . https://web.archive.org/web/20150325081230/http://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2014/november/cannabinoider-foreslas-bli-klassade-som-halsofarlig-vara/ . 25 March 2015 . sv . 29 June 2015 . Folkhalsomyndigheten . Public Health Agency of Sweden .
6. Web site: Schedules of Controlled Substances: Temporary Placement of 10 Synthetic Cathinones Into Schedule I . U.S. Federal Register . Drug Enforcement Administration . 7 March 2014 .