Pentolame Explained

Pentolame, also known as 17β-((5-hydroxypentyl)amino)estradiol is a synthetic, steroidal estrogen and a 17β-aminoestrogen with anticoagulant effects that was first described in 1993 and was never marketed.[1] [2] [3]

Notes and References

  1. Lemini C, Rubio-Póo C, Silva G, García-Mondragón J, Zavala E, Mendoza-Patiño N, Castro D, Cruz-Almanza R, Mandoki JJ . Anticoagulant and estrogenic effects of two new 17 beta-aminoestrogens, butolame [17 beta-(4-hydroxy-1-butylamino)-1,3,5(10)-estratrien-3-ol] and pentolame [17 beta-(5-hydroxy-1-pentylamino)-1,3,5(10)-estratrien-3-ol] . Steroids . 58 . 10 . 457–61 . 1993 . 8256254 . 10.1016/0039-128x(93)90002-5. 54381037 .
  2. Lemus AE, Jaimez R, Lemini C, Menjivar M, Silva G, Rubio-Poo C, Valenzuela F, Larrea F . Estrogenic effects of the synthetic aminoestrogen 17 beta-(5-hydroxy-1-pentylamino)-1,3,5(10)-estratrien-3-ol (pentolame) . Steroids . 63 . 7–8 . 433–8 . 1998 . 9654651 . 10.1016/s0039-128x(98)00046-4. 13582499 .
  3. Jaimez R, Cooney A, Jackson K, Lemus AE, Lemini C, Cárdenas M, García R, Silva G, Larrea F . In vivo estrogen bioactivities and in vitro estrogen receptor binding and transcriptional activities of anticoagulant synthetic 17beta-aminoestrogens . J. Steroid Biochem. Mol. Biol. . 73 . 1–2 . 59–66 . 2000 . 10822025 . 10.1016/s0960-0760(00)00053-4. 40211307 .

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