Pentalenolactone synthase explained

Pentalenolactone synthase
Ec Number:	1.14.19.8

Pentalenolactone synthase (Formerly, penM (gene), pntM (gene)) is an enzyme with systematic name pentalenolactone-F:oxidized-ferredoxin oxidoreductase (pentalenolactone forming).^[1] This enzyme catalyse the following chemical reaction

\rightleftharpoons pentalenolactone + reduced ferredoxin

This is heme-thiolate protein (P-450), which is isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae.

Notes and References

1. Zhu D, Seo MJ, Ikeda H, Cane DE . Genome mining in streptomyces. Discovery of an unprecedented P450-catalyzed oxidative rearrangement that is the final step in the biosynthesis of pentalenolactone . Journal of the American Chemical Society . 133 . 7 . 2128–31 . February 2011 . 21284395 . 3041837 . 10.1021/ja111279h .