Pentalenic acid synthase explained

Pentalenic acid synthase
Ec Number:	1.14.15.11

Pentalenic acid synthase (CYP105D7, sav7469 (gene)) is an enzyme with systematic name .^[1] This enzyme catalyses the following chemical reaction

1-deoxypentalenate + reduced ferredoxin + O₂

\rightleftharpoons pentalenate + oxidized ferredoxin + H₂O

Pentalenic acid synthase is a heme-thiolate enzyme (P-450).

Notes and References

1. Takamatsu S, Xu LH, Fushinobu S, Shoun H, Komatsu M, Cane DE, Ikeda H . Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis . The Journal of Antibiotics . 64 . 1 . 65–71 . January 2011 . 21081950 . 3030646 . 10.1038/ja.2010.135 .