Paternal mtDNA transmission explained

In genetics, paternal mtDNA transmission and paternal mtDNA inheritance refer to the incidence of mitochondrial DNA (mtDNA) being passed from a father to his offspring. Paternal mtDNA inheritance is observed in a small proportion of species; in general, mtDNA is passed unchanged from a mother to her offspring,[1] making it an example of non-Mendelian inheritance. In contrast, mtDNA transmission from both parents occurs regularly in certain bivalves.

In animals

Paternal mtDNA inheritance in animals varies. For example, in Mytilidae mussels, paternal mtDNA "is transmitted through the sperm and establishes itself only in the male gonad."[2] [3] [4] In testing 172 sheep, "The Mitochondrial DNA from three lambs in two half-sib families were found to show paternal inheritance."[5] An instance of paternal leakage resulted in a study on chickens.[6] There has been evidences that paternal leakage is an integral part of mitochondrial inheritance of Drosophila simulans.[7]

In humans

In human mitochondrial genetics, there is debate over whether or not paternal mtDNA transmission is possible. Many studies hold that paternal mtDNA is never transmitted to offspring.[8] This thought is central to mtDNA genealogical DNA testing and to the theory of mitochondrial Eve. The fact that mitochondrial DNA is maternally inherited enables researchers to trace maternal lineage far back in time. Y chromosomal DNA, paternally inherited, is used in an analogous way to trace the agnate lineage.

In sexual reproduction, paternal mitochondria found in the sperm are actively decomposed, thus preventing "paternal leakage". Mitochondria in mammalian sperm are usually destroyed by the egg cell after fertilization. In 1999 it was reported that paternal sperm mitochondria (containing mtDNA) are marked with ubiquitin to select them for later destruction inside the embryo.[9] Some in vitro fertilization (IVF) techniques, particularly intracytoplasmic sperm injection (ICSI) of a sperm into an oocyte, may interfere with this.

It is now understood that the tail of the sperm, which contains additional mtDNA, may also enter the egg. This had led to increased controversy about the fate of paternal mtDNA.

Some sources state that so little paternal mtDNA is transmitted as to be negligible ("At most, one presumes it must be less than 1 in 1000, since there are 100 000 mitochondria in the human egg and only 100 in the sperm (Satoh and Kuroiwa, 1991).") or that paternal mtDNA is so rarely transmitted as to be negligible ("Nevertheless, studies have established that paternal mtDNA is so rarely transmitted to offspring that mtDNA analyses remain valid..."[10]). A few studies indicate that, very rarely, a small portion of a person's mitochondria can be inherited from the father.[11] [12]

The controversy about human paternal leakage was summed up in the 1996 study Misconceptions about mitochondria and mammalian fertilization: Implications for theories on human evolution, which was peer-reviewed and printed in Proceedings of the National Academy of Sciences.[13] According to the study's abstract:

The mixing of maternal and paternal mtDNA was thought to have been found in chimpanzees in 1999[14] and in humans in 1999[15] and 2018. This last finding is significant, as biparental mtDNA was observed in subsequent generations in three different families leading to the conclusion that, although the maternal transmission dogma remains strong, there is evidence that paternal transmission does exist and there is a probably a mechanism which, if elucidated, can be a new tool in the reproductive field (e.g. avoiding mitochondrial replacement therapy, and just using this mechanism so that the offspring inherit the paternal mitochondria).[16] However, there has been only a single documented case among humans in which as much as 90% of a single tissue type's mitochondria was inherited through paternal transmission.[17]

According to the 2005 study More evidence for non-maternal inheritance of mitochondrial DNA?,[18] heteroplasmy is a "newly discovered form of inheritance for mtDNA. Heteroplasmy introduces slight statistical uncertainty in normal inheritance patterns."[19] Heteroplasmy may result from a mutation during development which is propagated to only a subset of the adult cells, or may occur when two slightly different mitochondrial sequences are inherited from the mother as a result of several hundred mitochondria being present in the ovum. However, the 2005 study states:

A study published in PNAS in 2018 titled Biparental Inheritance of Mitochondrial DNA in Humans has found paternal mtDNA in 17 individuals from three unrelated multigeneration families with a high level of mtDNA heteroplasmy (ranging from 24 to 76%) in a total of 17 individuals.[20]

In protozoa

Some organisms, such as Cryptosporidium, have mitochondria with no DNA whatsoever.[21]

In plants

In plants, it has also been reported that mitochondria can occasionally be inherited from the father, e.g. in bananas. Some Conifers also show paternal inheritance of mitochondria, such as the coast redwood, Sequoia sempervirens.

See also

External links

Notes and References

  1. Birky. C. William. 2001-12-01. The Inheritance of Genes in Mitochondria and Chloroplasts: Laws, Mechanisms, and Models. Annual Review of Genetics. 35. 1. 125–148. 10.1146/annurev.genet.35.102401.090231. 11700280. 0066-4197.
  2. Zouros E . The exceptional mitochondrial DNA system of the mussel family Mytilidae . Genes Genet. Syst. . 75 . 6 . 313–8 . December 2000 . 11280005 . 10.1266/ggs.75.313 . free .
  3. Sutherland B, Stewart D, Kenchington ER, Zouros E . The fate of paternal mitochondrial DNA in developing female mussels, Mytilus edulis: implications for the mechanism of doubly uniparental inheritance of mitochondrial DNA . Genetics . 148 . 1 . 341–7 . 1 January 1998. 10.1093/genetics/148.1.341 . 9475744 . 1459795 .
  4. http://mbe.library.arizona.edu/data/1995/1205/3stew.pdf Male and Female Mitochondrial DNA Lineages in the Blue Mussel (Mytilus edulis) Species Group
  5. Zhao X, Li N, Guo W, etal . Further evidence for paternal inheritance of mitochondrial DNA in the sheep (Ovis aries) . Heredity . 93 . 4 . 399–403 . October 2004 . 15266295 . 10.1038/sj.hdy.6800516 . free .
  6. Michelle Alexander . Simon Y. W. Ho . Martyna Molak . Ross Barnett . Örjan Carlborg . Ben Dorshorst . Christa Honaker . Francois Besnier . Per Wahlberg . Keith Dobney . Keith Dobney . Paul Siegel . Leif Andersson . Greger Larson . September 30, 2015 . Mitogenomic analysis of a 50-generation chicken pedigree reveals a rapid rate of mitochondrial evolution and evidence for paternal mtDNA inheritance . Biology Letters . The Royal Society . 11 . 10 . 10.1098/rsbl.2015.0561 . 26510672 . 4650172 . 20150561.
  7. J N Wolff . M Nafisinia . P Sutovsky . J W O Ballard . Paternal transmission of mitochondrial DNA as an integral part of mitochondrial inheritance in metapopulations of Drosophila simulans . Heredity . 110 . 1 . 57–62 . September 2012 . 23010820 . 10.1038/hdy.2012.60 . 3522233.
  8. e.g. Giles RE, Blanc H, Cann HM, Wallace DC . Maternal inheritance of human mitochondrial DNA . Proc. Natl. Acad. Sci. U.S.A. . 77 . 11 . 6715–9 . November 1980 . 6256757 . 350359. 10.1073/pnas.77.11.6715. 1980PNAS...77.6715G . free .
  9. Sutovsky P, Moreno RD, Ramalho-Santos J, Dominko T, Simerly C, Schatten G . Ubiquitin tag for sperm mitochondria . Nature . 402 . 6760 . 371–2 . November 1999 . 10586873 . 10.1038/46466 . 205054671 .
  10. [Evolutionary biology|evolutionary biologist]
  11. https://www.newscientist.com/article/dn2716-mitochondria-can-be-inherited-from-both-parents.html Mitochondria can be inherited from both parents
  12. Web site: Mitochondria can be inherited from both parents.
  13. Ankel-Simons F, Cummins JM . Misconceptions about mitochondria and mammalian fertilization: Implications for theories on human evolution . Proc. Natl. Acad. Sci. U.S.A. . 93 . 24 . 13859–63 . November 1996 . 8943026 . 19448 . 10.1073/pnas.93.24.13859. 1996PNAS...9313859A . free .
  14. . Linkage disequilibrium and recombination in hominid mitochondrial DNA . Science . 286 . 5449 . 2524–5 . December 1999 . 10617471 . 10.1126/science.286.5449.2524. as PDF
  15. Strauss E. December 1999. Human genetics. mtDNA shows signs of paternal influence. Science. 286. 5449. 2436a–2436. 10.1126/science.286.5449.2436a. 10636798. 82748115.
  16. Luo. Shiyu. Valencia. C. Alexander. Zhang. Jinglan. Lee. Ni-Chung. Slone. Jesse. Gui. Baoheng. Wang. Xinjian. Li. Zhuo. Dell. Sarah. 2018-11-21. Biparental Inheritance of Mitochondrial DNA in Humans. Proceedings of the National Academy of Sciences. 115. 51. en. 13039–13044. 10.1073/pnas.1810946115. 0027-8424. 30478036. 6304937. 2018PNAS..11513039L . free.
  17. Schwartz M, Vissing J . Paternal inheritance of mitochondrial DNA . N. Engl. J. Med. . 347 . 8 . 576–80 . 2002 . 12192017 . 10.1056/NEJMoa020350. free .
  18. Bandelt HJ . Kong QP . Parson W . Salas A. . amp . More evidence for non-maternal inheritance of mitochondrial DNA? . . May 27, 2005 . 957–60 . 42 . 12 . 15923271 . 10.1136/jmg.2005.033589 . 1735965 .
  19. http://www.rastafarispeaks.com/cgi-bin/forum/archive0/config.pl?noframes;read=7818 Re: Most-recent common ancestor
  20. Luo. Shiyu. Valencia. C. Alexander. Zhang. Jinglan. Lee. Ni-Chung. Slone. Jesse. Gui. Baoheng. Wang. Xinjian. Li. Zhuo. Dell. Sarah. Brown. Jenice. Chen. Stella Maris. 2018-11-26. Biparental Inheritance of Mitochondrial DNA in Humans. Proceedings of the National Academy of Sciences. en. 115. 51. 13039–13044. 10.1073/pnas.1810946115. 30478036. 6304937. 2018PNAS..11513039L . 0027-8424. free.
  21. Henriquez FL, Richards TA, Roberts F, McLeod R, Roberts CW . The unusual mitochondrial compartment of Cryptosporidium parvum . Trends Parasitol. . 21 . 2 . 68–74 . February 2005 . 15664529 . 10.1016/j.pt.2004.11.010 .

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