Passenger leukocyte explained

In tissue and organ transplantation, the passenger leukocyte theory is the proposition that leucocytes within a transplanted allograft sensitize the recipient's alloreactive T-lymphocytes, causing transplant rejection.^[1]

The concept was first proposed by George Davis Snell^[2] and the term coined in 1968 when Elkins and Guttmann showed that leukocytes present in a donor graft initiate an immune response in the recipient of a transplant.^[3]

See also

• History of immunology

Further reading

• Audet . Maxime . Panaro . Fabrizio . Piardi . Tullio . Huang . Ping . Cag . Murat . Cinqualbre . Jacques . Wolf . Philippe . Passenger Lymphocyte Syndrome and Liver Transplantation . Clinical and Developmental Immunology . 2008 . 715769 . 2008 . 19277202 . 2652582 . 10.1155/2008/715769 . free .
• Demetris . AJ . Murase . N . Rao . AS . Fung . JJ . Starzl . TE . The dichotomous functions of passenger leukocytes in solid-organ transplantation . Advances in Nephrology from the Necker Hospital . 24 . 341–54 . 1995 . 7572418 . 2987699 .

Notes and References

1. Book: Olivier . Thaunat . Emmanuel . Morelon . Modulation of Immunogenicity . https://books.google.com/books?id=McxJAAAAQBAJ&pg=PA210 . 210–1 . Marco . Lanzetta . Jean-Michel . Dubernard . 2007 . Hand transplantation . Springer . 978-88-470-0374-3 .
2. Snell . George D. . The homograft reaction . Annual Review of Microbiology . 11 . 439–58 . 1957 . 13470828 . 10.1146/annurev.mi.11.100157.002255 .
3. Elkins . William L. . Guttmann . Ronald D. . Pathogenesis of a local graft versus host reaction: immunogenicity of circulating host leukocytes . Science . 159 . 3820 . 1250–1 . 1968 . 4886081 . 10.1126/science.159.3820.1250 . 1968Sci...159.1250E . 84424102 .