Para-Iodoamphetamine Explained

para-Iodoamphetamine (PIA), also known as 4-iodoamphetamine (4-IA), is a research chemical of the phenethylamine and amphetamine chemical classes.

It acts as a selective serotonin releasing agent and is also a MAOI.^[1]

PIA is rumored to be a serotonergic neurotoxin on the account of that being reported to be the case for para-chloroamphetamine.

However, PIA is a much weaker 5-HT neurotoxin than is the case for PCA.^[2]

Analogs

5-IAI was an attempt to make a non-neurotoxic analog of PIA.

See also

• p-Bromoamphetamine
• p-Chloroamphetamine
• p-Fluoroamphetamine
• Iofetamine

Notes and References

1. Marona-Lewicka D, Rhee GS, Sprague JE, Nichols DE . Psychostimulant-like effects of p-fluoroamphetamine in the rat . European Journal of Pharmacology . 287 . 2 . 105–13 . December 1995 . 8749023 . 10.1016/0014-2999(95)00478-5 .
2. Nichols DE, Johnson MP, Oberlender R . 5-Iodo-2-aminoindan, a nonneurotoxic analogue of p-iodoamphetamine . Pharmacology, Biochemistry, and Behavior . 38 . 1 . 135–9 . January 1991 . 1826785 . 10.1016/0091-3057(91)90601-W . 10.1.1.670.504 . 20485505 .