Paper spray ionization explained

Paper spray ionization is a technique used in mass spectrometry to produce ions from a sample to be analyzed. It is a variant of electrospray ionization.[1] The sample (for instance a few microlitres of blood or urine) is applied to a piece of paper and solvent is added. Then a high voltage is applied, which creates the ions to be analyzed with a mass spectrometer. The method, first described in 2010,[2] is relatively easy to use and can detect and measure the presence of various substances in the sample. This technique shows great potential for point-of-care clinical applications, in that important tests may be run and results obtained within a reasonable amount of time in proximity to the patient in a single visit.[3]

In 2017 it was reported that a test based on paper spray ionization mass spectrometry can detect cocaine use from a subject's fingerprint.[4] It was also used to detect pesticides from the surfaces of fruits. [5]

Notes and References

  1. Meher. Anil Kumar. Chen. Yu-Chie. 2017. Electrospray Modifications for Advancing Mass Spectrometric Analysis. Mass Spectrometry. 6. Spec Iss. S0057 . 10.5702/massspectrometry.S0057. 5448333. 28573082.
  2. Liu. Jiangjiang. Wang. He. Manicke. Nicholas E.. Lin. Jin-Ming. Cooks. R. Graham. Ouyang. Zheng. 2010-03-15. Development, characterization, and application of paper spray ionization. Analytical Chemistry. 82. 6. 2463–2471. 10.1021/ac902854g. 20158226.
  3. Damon. Deidre E.. Davis. Kathryn M.. Moreira. Camila R.. Capone. Patricia. Cruttenden. Riley. Badu-Tawiah. Abraham K.. 2016-02-02. Direct Biofluid Analysis Using Hydrophobic Paper Spray Mass Spectrometry. Analytical Chemistry. en. 88. 3. 1878–1884. 10.1021/acs.analchem.5b04278. 26730614 . 0003-2700.
  4. News: New Fingerprint Test Can Detect Cocaine Use In Seconds. Glatter. Robert. September 23, 2017. Forbes. en.
  5. Soparwalla . Santosh . Tadjimukhamedov . Fatkhulla K. . Wiley . Joshua S. . Ouyang . Zheng . Cooks . R. Graham . 2011 . In situ analysis of agrochemical residues on fruit using ambient ionization on a handheld mass spectrometer . Analyst . 136 . 21. 4392–4396 . 10.1039/C1AN15493A . 21892448 .

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