Pantoate 4-dehydrogenase explained

pantoate 4-dehydrogenase
Ec Number:	1.1.1.106
Cas Number:	37250-38-7
Go Code:	0050166

In enzymology, a pantoate 4-dehydrogenase is an enzyme that catalyzes the chemical reaction

(R)-pantoate + NAD⁺

\rightleftharpoons (R)-4-dehydropantoate + NADH + H⁺

Thus, the two substrates of this enzyme are (R)-pantoate and NAD⁺, whereas its 3 products are (R)-4-dehydropantoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-pantoate:NAD⁺ 4-oxidoreductase. Other names in common use include pantoate dehydrogenase, pantothenase, and D-pantoate:NAD⁺ 4-oxidoreductase. This enzyme participates in pantothenate and coa biosynthesis.

References

• Goodhue CT, Snell EE . 1966 . The bacterial degradation of pantothenic acid. 3. Enzymatic formation of aldopantoic acid . Biochemistry . 5 . 403 - 8 . 4287370 . 10.1021/bi00866a003 . 2 .