Pantoate—beta-alanine ligase explained

Pantoate—β-alanine ligase
Ec Number:	6.3.2.1
Cas Number:	9023-49-8
Go Code:	0004592

In enzymology, a pantoate—β-alanine ligase is an enzyme that catalyzes the chemical reaction

ATP + (R)-pantoate + β-alanine

\rightleftharpoons AMP + diphosphate + (R)-pantothenate

The 3 substrates of this enzyme are ATP, (R)-pantoate, and beta-alanine, whereas its 3 products are AMP, diphosphate, and (R)-pantothenate.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is (R)-pantoate:beta-alanine ligase (AMP-forming). Other names in common use include pantothenate synthetase, pantoate activating enzyme, pantoic-activating enzyme, and D-pantoate:beta-alanine ligase (AMP-forming). This enzyme participates in beta-alanine metabolism and pantothenate and CoA biosynthesis.

Structural studies

As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,,,,,, and .

References

• GINOZA HS, ALTENBERN RA . 1955 . The pantothenate-synthesizing enzyme in cell-free extracts of Brucella abortus, strain 19 . Arch. Biochem. . 56 . 537 - 41 . 14377603 . 10.1016/0003-9861(55)90273-3 . 2 .
• MAAS WK . 1952 . Pantothenate studies. III. Description of the extracted pantothenate-synthesizing enzyme of Escherichia coli . J. Biol. Chem. . 198 . 23 - 32 . 12999714 . 1 .
• Maas WK . 1956 . Mechanism of the enzymatic synthesis of pantothenate from beta-alanine and pantoate . Fed. Proc. . 15 . 305 - 306 .