Pantetheine hydrolase explained

Pantetheine hydrolase
Ec Number:	3.5.1.92

In enzymology, a pantetheine hydrolase is an enzyme that catalyzes the chemical reaction

(R)-pantetheine + H₂O

\rightleftharpoons (R)-pantothenate + 2-aminoethanethiol

Thus, the two substrates of this enzyme are (R)-pantetheine and H₂O, whereas its two products are (R)-pantothenate and 2-aminoethanethiol.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is (R)-pantetheine amidohydrolase. Other names in common use include pantetheinase, vanin, and vanin-1. This enzyme participates in pantothenate and CoA biosynthesis.

Further reading

• Book: Dupre S, Cavallini D . Purification and properties of pantetheinase from horse kidney . 1979 . Vitamins and Coenzymes Part D . 62 . 262–7 . 440106 . 10.1016/0076-6879(79)62227-9 . Methods in Enzymology . 978-0-12-181962-0 .
• Dupre S, Chiaraluce R, Nardini M, Cannella C, Ricci G, Cavallini D . 1984 . Continuous spectrophotometric assay of pantetheinase activity . Anal. Biochem. . 142 . 175–81 . 6549111 . 10.1016/0003-2697(84)90534-7 . 1 .
• Maras B, Barra D, Dupre S, Pitari G . 1999 . Is pantetheinase the actual identity of mouse and human vanin-1 proteins? . FEBS Lett. . 461 . 149–52 . 10567687 . 10.1016/S0014-5793(99)01439-8 . 3 .
• P . 1996 . Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing . Immunity . 5 . 391–405 . 8934567 . 10.1016/S1074-7613(00)80496-3 . Galland . F . Bazin . H . Zakharyev . VM . Imhof . BA . Naquet . P . 5 . free .
• Maras B, Dupre S, Naquet P, Galland F . 2000 . Pantetheinase activity of membrane-bound Vanin-1: lack of free cysteamine in tissues of Vanin-1 deficient mice . FEBS Lett. . 483 . 149–54 . 11042271 . 10.1016/S0014-5793(00)02110-4 . 2–3 . free .
• Granjeaud S, Mattei MG, Mungall AJ, Naquet P, Galland F . 2001 . Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes . Immunogenetics . 53 . 296–306 . 11491533 . 10.1007/s002510100327 . 4 .
• Pace HC, Brenner C . 2001 . The nitrilase superfamily: classification, structure and function . Genome Biol. . 2 . REVIEWS0001 . 11380987 . 1 . 150437 . 10.1186/gb-2001-2-1-reviews0001 . free .