Pantetheine-phosphate adenylyltransferase explained

pantetheine-phosphate adenylyltransferase
Ec Number:2.7.7.3
Cas Number:9026-99-7
Go Code:0004595

In enzymology, a pantetheine-phosphate adenylyltransferase is an enzyme that catalyzes the chemical reaction

ATP + 4'-Phosphopantetheine

\rightleftharpoons

diphosphate + 3'-dephospho-CoA

Thus, the two substrates of this enzyme are ATP and 4'-Phosphopantetheine, whereas its two products are diphosphate and 3'-dephospho-CoA.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:pantetheine-4'-phosphate adenylyltransferase. Other names in common use include dephospho-CoA pyrophosphorylase, pantetheine phosphate adenylyltransferase, dephospho-coenzyme A pyrophosphorylase, and 3'-dephospho-CoA pyrophosphorylase. This enzyme participates in pantothenate and coa biosynthesis.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,, and .

References

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Pantetheine-phosphate adenylyltransferase".

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