PLDN explained

Pallidin is a protein that in humans is encoded by the PLDN gene.^{[1] [2]}

Function

The protein encoded by this gene may play a role in intracellular vesicle trafficking. It interacts with Syntaxin 13 which mediates intracellular membrane fusion. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Interactions

PLDN has been shown to interact with:

• BLOC1S1,^[3]
• BLOC1S2,^[3]
• CNO,^[3]
• Dysbindin,^[3]
• MUTED,^{[3] [4]}
• SNAPAP,^[3] and
• STX12.

Further reading

• Falcón-Pérez JM, Dell'Angelica EC . The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis . Pigment Cell Res. . 15 . 2 . 82–6 . 2002 . 11936273 . 10.1034/j.1600-0749.2002.1r082.x . free .
• Korsgren C, Cohen CM . Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3 . J. Biol. Chem. . 263 . 21 . 10212–8 . 1988 . 10.1016/S0021-9258(19)81500-4 . 2968981 . free .
• Azim AC, Marfatia SM, Korsgren C, Dotimas E, Cohen CM, Chishti AH . Human erythrocyte dematin and protein 4.2 (pallidin) are ATP binding proteins . Biochemistry . 35 . 9 . 3001–6 . 1996 . 8608138 . 10.1021/bi951745y .
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Risinger MA, Korsgren C, Cohen CM . Role of N-myristylation in targeting of band 4.2 (pallidin) in nonerythroid cells . Exp. Cell Res. . 229 . 2 . 421–31 . 1997 . 8986625 . 10.1006/excr.1996.0387 .
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
• Falcón-Pérez JM, Starcevic M, Gautam R, Dell'Angelica EC . BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules . J. Biol. Chem. . 277 . 31 . 28191–9 . 2002 . 12019270 . 10.1074/jbc.M204011200 . free .
• Moriyama K, Bonifacino JS . Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles . Traffic . 3 . 9 . 666–77 . 2003 . 12191018 . 10.1034/j.1600-0854.2002.30908.x . free .
• Ciciotte SL, Gwynn B, Moriyama K, Huizing M, Gahl WA, Bonifacino JS, Peters LL . Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1) . Blood . 101 . 11 . 4402–7 . 2003 . 12576321 . 10.1182/blood-2003-01-0020 . free .
• Li W, Zhang Q, Oiso N, Novak EK, Gautam R, O'Brien EP, Tinsley CL, Blake DJ, Spritz RA, Copeland NG, Jenkins NA, Amato D, Roe BA, Starcevic M, Dell'Angelica EC, Elliott RW, Mishra V, Kingsmore SF, Paylor RE, Swank RT . Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) . Nat. Genet. . 35 . 1 . 84–9 . 2003 . 12923531 . 2860733 . 10.1038/ng1229 .
• Starcevic M, Dell'Angelica EC . Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1) . J. Biol. Chem. . 279 . 27 . 28393–401 . 2004 . 15102850 . 10.1074/jbc.M402513200 . free .
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .

Notes and References

1. Huang L, Kuo YM, Gitschier J . The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency . Nat Genet . 23 . 3 . 329–32 . Dec 1999 . 10610180 . 10.1038/15507 . 22843205 .
2. Web site: Entrez Gene: PLDN pallidin homolog (mouse).
3. Starcevic M, Dell'Angelica EC . Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1) . J. Biol. Chem. . 279 . 27 . 28393–401 . Jul 2004 . 15102850 . 10.1074/jbc.M402513200 . free .
4. Falcón-Pérez JM, Starcevic M, Gautam R, Dell'Angelica EC . BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules . J. Biol. Chem. . 277 . 31 . 28191–9 . Aug 2002 . 12019270 . 10.1074/jbc.M204011200 . free .