P87PIKAP explained
| Phosphoinositide-3-kinase adapter protein of 87 kDa |
| Hgncid: | 27101 |
| Symbol: | p87PIKAP |
| Altsymbols: | p84,PIK3R6 |
| Entrezgene: | 146850 |
| Uniprot: | Q5UE93 |
| Omim: | 611462 |
| Chromosome: | 17 |
| Arm: | p |
| Band: | 13.1 |
Within molecular and cell biology, p87PIKAP is a regulatory subunit of the type IB Phosphoinositide 3-Kinase p110γ that is highly expressed in the heart and is present in dendritic cells, macrophages, and neutrophils.[1] It is also referred to as p84 and p87.[2] Some studies have found P87PIKAP to have a role in carcinogenesis.[3]
Notes and References
- Voigt P, Dorner MB, Schaefer M . Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B . The Journal of Biological Chemistry . 281 . 15 . 9977–86 . 2006 . 16476736 . 10.1074/jbc.M512502200 . free .
- Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, Schaefer M, Gohla A, Harteneck C, Wymann MP, Jeanclos E, Nürnberg B . 6 . Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma . Proceedings of the National Academy of Sciences of the United States of America . 106 . 48 . 20312–7 . 2009 . 19906996 . 2787109 . 10.1073/pnas.0905506106 . 2009PNAS..10620312K . free .
- Differential roles for the p101 and p84 regulatory subunits of PI3Kc in tumor growth and metastasis. JA . Brazzatti. etal. Oncogene. 2012. 31. 18. 2350–2361. 10.1038/onc.2011.414. 21996737. 24708435. free.
